Estriol + Niacinamide + GHK-Cu + HA Cream

Only good stuff

Each ingredient in this formula targets a different layer of what makes skin look and feel younger. Estriol, a mild topical estrogen, activates your skin’s estrogen receptors to stimulate collagen and rebuild thickness that declines with age. Niacinamide (vitamin B3) strengthens your skin barrier, calms inflammation, and helps even out tone. GHK-Cu, a naturally occurring copper peptide, signals your skin cells to ramp up collagen and elastin production while supporting repair. Hyaluronic acid draws moisture into the skin and holds it there, keeping your complexion plump and hydrated throughout the day. Together, they work as a system rather than a single ingredient.

Each ingredient in this formulation has its own well-established research history. Estriol has been studied as a topical skin treatment since the mid-1990s, with clinical trials showing significant improvements in elasticity, hydration, and wrinkle depth in postmenopausal women. Niacinamide has decades of clinical evidence supporting its role in barrier repair, hydration, and tone correction. GHK-Cu was first isolated from human blood plasma in 1973 and has since been shown to stimulate collagen production and support skin remodeling. Hyaluronic acid is one of the most widely used hydrating ingredients in dermatology, with proven ability to attract and retain moisture in the skin.

This cream is generally well tolerated. Some users may experience mild redness or slight irritation as their skin adjusts to the active ingredients, particularly during the first week or two. These effects typically resolve on their own.