Estriol + Tretinoin Cream
Estriol/Tretinoin Cream combines a gentle topical estrogen with a proven retinoid to restore firmness, smooth fine lines, and deeply hydrate skin that has changed with age or hormonal shifts.
Who is this for? For women noticing skin changes with age or menopause who want the most powerful topical combination available. Combines hormonal support with prescription-strength retinoid resurfacing.
Restores firmness and elasticity to aging skin
Smooths fine lines and improves skin texture
Boosts hydration from within the skin
Supports collagen production at two levels
* Price reflects a 6-month treatment plan. For research purposes only.
Only good stuff
This cream pairs two well-established active ingredients that target aging skin in complementary ways. Estriol, a mild form of estrogen, works at the skin’s foundation to stimulate collagen and elastin production while restoring moisture that declines with age. Tretinoin, a prescription-strength retinoid, accelerates cell turnover on the surface, clearing away dull, damaged cells so fresher, smoother skin can take their place. Together, they address both the structural and surface-level changes that make skin look and feel older.
Tretinoin has been used in dermatology for nearly 50 years and remains one of the most extensively studied topical anti-aging ingredients available. Estriol, a naturally occurring form of estrogen produced in higher quantities during pregnancy, has been researched as a topical skin treatment since the mid-1990s. Clinical studies on postmenopausal women using topical estriol have shown significant improvements in skin elasticity, hydration, and wrinkle depth over 12 to 24 weeks of use. Both compounds are well-established in medical literature and have long safety records when used under physician supervision.
Some users may experience mild dryness, redness, or peeling as their skin adjusts to tretinoin, particularly during the first few weeks. These effects typically lessen with consistent use. Because tretinoin increases sun sensitivity, daily sunscreen is essential while using this product.
What Sets It Apart
Two Proven Ingredients, One Formula
Targets Aging at Every Level
Physician-Prescribed Strength
Designed for Changing Skin
Frequently asked questions
Estriol/Tretinoin cream has not been approved by the U.S. Food and Drug Administration as a combination product. It can only be prescribed through licensed clinicians where state law allows.
Yes. Both estriol and tretinoin have been studied extensively in human trials, individually and in combination. Clinical research on topical estriol has shown measurable improvements in skin thickness, elasticity, and wrinkle reduction in postmenopausal women.
Estriol restores moisture and supports collagen production from within, while tretinoin accelerates surface-level cell renewal. Together, they help skin feel firmer, smoother, and more hydrated over time.
Both ingredients have well-established safety profiles with decades of clinical use. Estriol acts locally on the skin with minimal systemic absorption. As with any active skincare product, use under the guidance of a licensed physician is recommended.
Pregnant or breastfeeding individuals should not use this product, as tretinoin is not recommended during pregnancy. Individuals with a history of estrogen-sensitive conditions should consult a medical professional before use.
Apply to clean, dry skin in the evening, as tretinoin is light-sensitive. Follow with sunscreen every morning. AIRA Skin offers this formula in 30g and 90g sizes, which you will select during your intake questionnaire for physician review.
Yes, though avoid layering with other strong actives (like additional retinoids or exfoliating acids) on the same evening. Your intake questionnaire will help determine which products work best together.
How AIRA works
Medical Intake
Prescription
Delivery
Why AIRA?
Your body already holds the blueprint — AIRA helps you unlock it. Our physician-guided peptide programs will help you perform, recover, and feel your best.
Chat with a provider 24/7
Trusted pharmacy
Manage goals in one place
Fast, discreet shipping
Start your new AIRA today
Unleash a healthier, more energetic version of yourself with AIRA. Check out treatments now and embark on your journey to a fulfilling life.
