Tretinoin Cream
Tretinoin 0.05% Cream is a prescription-strength retinoid that accelerates skin renewal, boosts collagen production, and visibly reduces fine lines, wrinkles, and uneven skin tone.
Who is this for? For anyone ready to invest in long-term skin quality. Works for all skin types, all genders, ages 25 and up.
Smooths fine lines and wrinkles
Evens out skin tone and fades dark spots
Boosts collagen for firmer, stronger skin
Accelerates your skin’s natural renewal process
* Price reflects a 6-month treatment plan. For research purposes only.
Only good stuff
Tretinoin is a prescription-strength form of vitamin A that speeds up the rate at which your skin replaces old, damaged cells with new ones. This faster turnover smooths the surface, fades discoloration, and clears congested pores. Beneath the surface, tretinoin stimulates collagen production, the protein that keeps skin firm and resilient. With consistent use, skin becomes smoother, more even, and visibly younger-looking over time.
Tretinoin has been used in dermatology for nearly 50 years, making it one of the most extensively studied topical treatments in medicine. Originally developed to treat acne, researchers quickly discovered its powerful anti-aging effects, including increased collagen production and reversal of sun damage. Large-scale clinical trials have consistently shown that tretinoin 0.05% significantly improves fine wrinkling, skin texture, and hyperpigmentation over 12 to 24 weeks of use. It remains the gold standard in prescription retinoid therapy.
Some users experience mild dryness, redness, or peeling during the first few weeks as their skin adjusts. This is sometimes called the “retinization” period and typically subsides with continued use. Tretinoin increases sun sensitivity, so daily sunscreen is essential.
What Sets It Apart
The Gold Standard in Retinoids
Prescription Strength, Real Results
Compounded for Quality
Works Below the Surface
Frequently asked questions
Tretinoin is FDA-approved for the treatment of acne and has been extensively studied for photoaging. AIRA Skin’s compounded formulation can only be prescribed through licensed clinicians where state law allows.
Yes. Tretinoin is one of the most clinically studied topical skin treatments available, with decades of human trials confirming its effects on wrinkles, skin texture, collagen production, and hyperpigmentation.
Tretinoin speeds up cell turnover so your skin sheds old, damaged cells faster and replaces them with fresher ones. It also stimulates collagen production, which helps skin stay firm and smooth over time.
Tretinoin has a well-established safety profile backed by nearly five decades of clinical use. Side effects are generally mild and temporary. As with any active skincare product, use under the guidance of a licensed physician is recommended.
Pregnant or breastfeeding individuals should not use tretinoin. Individuals with very sensitive skin or active eczema should consult a medical professional before starting treatment.
Apply to clean, dry skin in the evening, as tretinoin is light-sensitive. Follow with sunscreen every morning. If you are new to retinoids, your skin may need a few weeks to adjust.
Yes, though avoid layering with other strong actives (like exfoliating acids or additional retinoids) on the same evening. Your intake questionnaire will help determine which products work best together.
How AIRA works
Medical Intake
Prescription
Delivery
Why AIRA?
Your body already holds the blueprint — AIRA helps you unlock it. Our physician-guided peptide programs will help you perform, recover, and feel your best.
Chat with a provider 24/7
Trusted pharmacy
Manage goals in one place
Fast, discreet shipping
Start your new AIRA today
Unleash a healthier, more energetic version of yourself with AIRA. Check out treatments now and embark on your journey to a fulfilling life.
